Correlation between skin microbiota and its metabolome with chronic wound healing

Abstract

The aim of this work was to identify the predominant microrganisms in the microbiota of chronic wounds, seeking to understand its correlation with the healing of those wounds. An integrative literature review was performed in the PubMed database. Articles published in full, in English, published between 2016 and 2021, were selected. Articles that addressed the use of immunosuppressive drugs and/or use of antibiotics were excluded. To elaborate the study question, the PICO strategy (acronym for patient, intervention, comparison, outcomes) was used, which allows the identification of descriptors, which help to locate relevant primary studies in the databases. The delimited research question is: Is there a correlation between skin microbiota and chronic wound healing? The keywords were selected from the Health Science Descriptors, BVS and MeSH Database, with Boolean operators “AND” and “OR” for combination of terms. Twenty-eight articles were selected in three thematic categories. The main genera of microorganisms found in chronic skin wounds were Staphylococcus, Corynebacterium, Pseudomonas and Enterococcus. No indications of correlation with wound healing were found in the material analyzed. It is an important matter to contribute to the prevention of complications in chronic wounds, which can be caused by infectious microorganisms, and often result in amputation or death.