A utilização de antioxidantes orais na fotoproteção: revisão sistemática

Abstract

Excessive exposure to solar radiation is a major contributor to the development of skin cancer and photoaging. Oral photoprotection has been used as a new strategy for skin care, even though it is not used in place of topical sunscreens, it can act as a complement to these. Oral antioxidants appear to be good candidates for reducing damage mediated by ultraviolet radiation and preventing health consequences from overexposure. The objective of this study is to systematically review the use of oral antioxidants in photoprotection, identifying which are the main oral antioxidants with proven scientific evidence, showing the mechanism of action of each one, as well as demonstrating the possible effects on photoaging and skin cancer. For this, a search was carried out in the databases: Science Direct, Pubmed, Scielo and Lilacs. The criteria used for the selection of articles were: scientific articles related to the subject under study, articles available entirely on the internet and pre-clinical studies in vitro and in animals (in vivo) and clinical studies in humans. A total of 16 articles addressed substances that have potential antioxidants and that are candidates for providing photoprotective effects against UV radiation. However, no substance with proven scientific evidence was verified, regarding the mechanism of action, little evidence was found and these are still preliminary. And the anti-aging and anticarcinogenic effects, no substance showed the ability to mitigate these damages.